Urinary Tobacco Smoke-Constituent Biomarkers for Assessing Risk of Lung Cancer
Identifieur interne : 004D45 ( Main/Exploration ); précédent : 004D44; suivant : 004D46Urinary Tobacco Smoke-Constituent Biomarkers for Assessing Risk of Lung Cancer
Auteurs : Jian-Min Yuan [États-Unis] ; Lesley M. Butler [États-Unis] ; Irina Stepanov [États-Unis] ; Stephen S. Hecht [États-Unis]Source :
- Cancer research : (Chicago, Ill.) [ 0008-5472 ] ; 2014.
Descripteurs français
- KwdFr :
- Analyse multivariée, Cancérogènes (), Cotinine (urine), Fumée (effets indésirables), Glucuronides (urine), Humains, Hydrocarbures aromatiques polycycliques (urine), Marqueurs biologiques (urine), Nicotine (effets indésirables), Nitrosamines (urine), Phénanthrènes (urine), Pyridines (urine), Risque, Spectrométrie de masse, Tabac (), Tabac (effets indésirables), Tumeurs du poumon (diagnostic), Tumeurs du poumon (urine), Études prospectives, Évaluation des risques ().
- MESH :
- diagnostic : Tumeurs du poumon.
- effets indésirables : Fumée, Nicotine, Tabac.
- Pascal (Inist)
- Analyse multivariée, Cancérogènes, Cotinine, Glucuronides, Humains, Hydrocarbures aromatiques polycycliques, Marqueurs biologiques, Nitrosamines, Phénanthrènes, Pyridines, Risque, Spectrométrie de masse, Tabac, Tabagisme, Marqueur biologique, Facteur risque, Bronchopulmonaire, Cancer du poumon, Tumeurs du poumon, Études prospectives, Évaluation des risques.
- Wicri :
English descriptors
- KwdEn :
- Biological marker, Biomarkers (urine), Bronchopulmonary, Carcinogens (chemistry), Cotinine (urine), Glucuronides (urine), Humans, Lung Neoplasms (diagnosis), Lung Neoplasms (urine), Lung cancer, Mass Spectrometry, Multivariate Analysis, Nicotine (adverse effects), Nitrosamines (urine), Phenanthrenes (urine), Polycyclic Aromatic Hydrocarbons (urine), Prospective Studies, Pyridines (urine), Risk, Risk Assessment (methods), Risk factor, Smoke (adverse effects), Tobacco, Tobacco (adverse effects), Tobacco (chemistry), Tobacco smoking.
- MESH :
- chemical , adverse effects : Nicotine, Smoke.
- chemical , chemistry : Carcinogens.
- chemical , urine : Biomarkers, Cotinine, Glucuronides, Nitrosamines, Phenanthrenes, Polycyclic Aromatic Hydrocarbons, Pyridines.
- adverse effects : Tobacco.
- chemistry : Tobacco.
- diagnosis : Lung Neoplasms.
- methods : Risk Assessment.
- urine : Lung Neoplasms.
- Humans, Mass Spectrometry, Multivariate Analysis, Prospective Studies, Risk.
Abstract
Tobacco-constituent biomarkers are metabolites of specific compounds present in tobacco or tobacco smoke. Highly reliable analytic methods, based mainly on mass spectrometry, have been developed for quantitation of these biomarkers in both urine and blood specimens. There is substantial interindividual variation in smoking-related lung cancer risk that is determined in part by individual variability in the uptake and metabolism of tobacco smoke carcinogens. Thus, by incorporating these biomarkers in epidemiologic studies, we can potentially obtain a more valid and precise measure of in vivo carcinogen dose than by using self-reported smoking history, ultimately improving the estimation of smoking-related lung cancer risk. Indeed, we have demonstrated this by using a prospective study design comparing biomarker levels in urine samples collected from smokers many years before their development of cancer versus those in their smoking counterparts without a cancer diagnosis. The following urinary metabolites were associated with lung cancer risk, independent of smoking intensity and duration: cotinine plus its glucuronide, a biomarker of nicotine uptake; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), a biomarker of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK); and r-1-,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT), a biomarker of polycyclic aromatic hydrocarbons (PAH). These results provide several possible new directions for using tobacco smoke-constituent biomarkers in lung cancer prevention, including improved lung cancer risk assessment, intermediate outcome determination in prevention trials, and regulation of tobacco products.
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Butler</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Stepanov, Irina" sort="Stepanov, Irina" uniqKey="Stepanov I" first="Irina" last="Stepanov">Irina Stepanov</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Masonic Cancer Center, University of Minnesota</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Hecht, Stephen S" sort="Hecht, Stephen S" uniqKey="Hecht S" first="Stephen S." last="Hecht">Stephen S. Hecht</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Masonic Cancer Center, University of Minnesota</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Cancer research : (Chicago, Ill.)</title><title level="j" type="abbreviated">Cancer res. : (Chic. Ill.)</title><idno type="ISSN">0008-5472</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Cancer research : (Chicago, Ill.)</title><title level="j" type="abbreviated">Cancer res. : (Chic. Ill.)</title><idno type="ISSN">0008-5472</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological marker</term><term>Biomarkers (urine)</term><term>Bronchopulmonary</term><term>Carcinogens (chemistry)</term><term>Cotinine (urine)</term><term>Glucuronides (urine)</term><term>Humans</term><term>Lung Neoplasms (diagnosis)</term><term>Lung Neoplasms (urine)</term><term>Lung cancer</term><term>Mass Spectrometry</term><term>Multivariate Analysis</term><term>Nicotine (adverse effects)</term><term>Nitrosamines (urine)</term><term>Phenanthrenes (urine)</term><term>Polycyclic Aromatic Hydrocarbons (urine)</term><term>Prospective Studies</term><term>Pyridines (urine)</term><term>Risk</term><term>Risk Assessment (methods)</term><term>Risk factor</term><term>Smoke (adverse effects)</term><term>Tobacco</term><term>Tobacco (adverse effects)</term><term>Tobacco (chemistry)</term><term>Tobacco smoking</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse multivariée</term><term>Cancérogènes ()</term><term>Cotinine (urine)</term><term>Fumée (effets indésirables)</term><term>Glucuronides (urine)</term><term>Humains</term><term>Hydrocarbures aromatiques polycycliques (urine)</term><term>Marqueurs biologiques (urine)</term><term>Nicotine (effets indésirables)</term><term>Nitrosamines (urine)</term><term>Phénanthrènes (urine)</term><term>Pyridines (urine)</term><term>Risque</term><term>Spectrométrie de masse</term><term>Tabac ()</term><term>Tabac (effets indésirables)</term><term>Tumeurs du poumon (diagnostic)</term><term>Tumeurs du poumon (urine)</term><term>Études prospectives</term><term>Évaluation des risques ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Nicotine</term><term>Smoke</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Carcinogens</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Biomarkers</term><term>Cotinine</term><term>Glucuronides</term><term>Nitrosamines</term><term>Phenanthrenes</term><term>Polycyclic Aromatic Hydrocarbons</term><term>Pyridines</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Tobacco</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Tobacco</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Fumée</term><term>Nicotine</term><term>Tabac</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Risk Assessment</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Mass Spectrometry</term><term>Multivariate Analysis</term><term>Prospective Studies</term><term>Risk</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Analyse multivariée</term><term>Cancérogènes</term><term>Cotinine</term><term>Glucuronides</term><term>Humains</term><term>Hydrocarbures aromatiques polycycliques</term><term>Marqueurs biologiques</term><term>Nitrosamines</term><term>Phénanthrènes</term><term>Pyridines</term><term>Risque</term><term>Spectrométrie de masse</term><term>Tabac</term><term>Tabagisme</term><term>Marqueur biologique</term><term>Facteur risque</term><term>Bronchopulmonaire</term><term>Cancer du poumon</term><term>Tumeurs du poumon</term><term>Études prospectives</term><term>Évaluation des risques</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Tabac</term><term>Tabagisme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tobacco-constituent biomarkers are metabolites of specific compounds present in tobacco or tobacco smoke. Highly reliable analytic methods, based mainly on mass spectrometry, have been developed for quantitation of these biomarkers in both urine and blood specimens. There is substantial interindividual variation in smoking-related lung cancer risk that is determined in part by individual variability in the uptake and metabolism of tobacco smoke carcinogens. Thus, by incorporating these biomarkers in epidemiologic studies, we can potentially obtain a more valid and precise measure of in vivo carcinogen dose than by using self-reported smoking history, ultimately improving the estimation of smoking-related lung cancer risk. Indeed, we have demonstrated this by using a prospective study design comparing biomarker levels in urine samples collected from smokers many years before their development of cancer versus those in their smoking counterparts without a cancer diagnosis. The following urinary metabolites were associated with lung cancer risk, independent of smoking intensity and duration: cotinine plus its glucuronide, a biomarker of nicotine uptake; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), a biomarker of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK); and r-1-,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT), a biomarker of polycyclic aromatic hydrocarbons (PAH). These results provide several possible new directions for using tobacco smoke-constituent biomarkers in lung cancer prevention, including improved lung cancer risk assessment, intermediate outcome determination in prevention trials, and regulation of tobacco products.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li></settlement><orgName><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name></region><name sortKey="Butler, Lesley M" sort="Butler, Lesley M" uniqKey="Butler L" first="Lesley M." last="Butler">Lesley M. Butler</name><name sortKey="Butler, Lesley M" sort="Butler, Lesley M" uniqKey="Butler L" first="Lesley M." last="Butler">Lesley M. Butler</name><name sortKey="Hecht, Stephen S" sort="Hecht, Stephen S" uniqKey="Hecht S" first="Stephen S." last="Hecht">Stephen S. Hecht</name><name sortKey="Stepanov, Irina" sort="Stepanov, Irina" uniqKey="Stepanov I" first="Irina" last="Stepanov">Irina Stepanov</name><name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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